Comparative Genomics and Genetics at Uppsala University
Atopic dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease triggered by allergic reactions, affecting both humans and dogs. There is a strong genetic predisposition, but development of atopic dermatitis is also influenced by environmental risk factors. We have identified a region on canine chromosome 27 as being associated with increased risk of developing canine atopic dermatitis (CAD) in German Shepherds. This region contains the gene PKP2 (plakophilin 2), encoding a desmosomal protein. Desmosomes are important to sustain a strong skin barrier.
Ongoing research includes genome-wide association studies of West Highland white terriers, boxers, Labrador retrievers, Golden retrievers and German shepherds to find further clues about the genetic risk factors for atopic dermatitis. We are continuously looking for more samples, so if you have a dog from any of these breeds affected by atopic dermatitis and would like to contribute to this research, please contact us for more information about how to submit a sample.